ea0094s3.2 | Emerging perspectives on reproductive hormones in breast and prostate cancer | SFEBES2023
Bleach Rachel
, Bozkurt Emir
, Dussmann Heiko
, Agbana Stephanie
, Shirran Sally
, Prehn Jochen
, McIlroy Marie
IntroductionAromatase Inhibitors (AI) are standard therapy for hormone receptor positive breast cancers in post-menopausal patients. Unfortunately, resistance is common and previous studies from our lab suggest that the altered steroid environment may be a driver. Using label-free mass spectrometry we set out to explore the unique androgen receptor (AR) interactome that supervenes in AI resistant breast cancer and associated hyper-androgenic environment....